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Hasanuddin, Silviana
- Antidepressant Activity and Identification of Chemical Compounds Extract Mustard Leaves (Brassica juncea L.)
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Authors
Affiliations
1 Departement of Pharmacy, STIKES Mandala Waluya Kendari, South-East Sulawesi, ID
1 Departement of Pharmacy, STIKES Mandala Waluya Kendari, South-East Sulawesi, ID
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3223-3227Abstract
Depression is a common disease that affects more than 300 million people of all ages which is generally accompanied by insomnia. In 2030 this disease is thought to be the biggest contributor to the burden of the disease worldwide. Mustard is one of the vegetables produced in Southeast Sulawesi, especially in the Wua-wua area, Kendari, where its use as a medicine is still lacking. This study aims to test the antidepressant activity of mustard leaf extract, and identify the class of extract chemical compounds. The long-term goal of this research is the manufacture of herbal preparations for either herbal or standardized herbs for the treatment of depression. Mustard leaf extract obtained from maceration contains flavonoids, saponins, sterols/triterpenoids, and terpenes. The testing of activities with the Open field test method, Forced swim test, and Tail suspension test of mice were carried out at several test doses (100 mg/kg bw, 200 mg/kg bw, and 400 mg/kg bw). The test results obtained was analyzed by One-way Analysis of Variance (ANOVA) (SPSS 16.0 program) indicating that the antidepressant effect shown in the extract dose of 100 mg/kg bw and 200 mg/kg bw.Keywords
Mustard Leaves, Depression, Insomnia, Chemical Compounds.References
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- Kim SY, Ahn SH, Kim HH. Antidepressive effects of Gami-Shinkiwhanin Immobilization stressed aging Mice. Research Journal of Pharmacy and Technology. 2018 May 30;11(5):1906-1916.
- In Silico Prediction of Metabolite in Petroselinum Crispum in Inhibiting Androgen Receptor as Treatment for Alopecia
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Authors
Silviana Hasanuddin
1,
Dolih Gozali
2,
Muhammad Arba
3,
Dwi Syah Fitra Ramadhan
4,
Resmi Mustarichie
1
Affiliations
1 Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang,, ID
2 Pharmaceutical Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang,, ID
3 Faculty of Pharmacy, Universitas Halu Oleo, Kendari,, ID
4 Department of Pharmacy, Universitas Mandala Waluya, Kendari,, ID
1 Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang,, ID
2 Pharmaceutical Department, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang,, ID
3 Faculty of Pharmacy, Universitas Halu Oleo, Kendari,, ID
4 Department of Pharmacy, Universitas Mandala Waluya, Kendari,, ID
Source
Research Journal of Pharmacy and Technology, Vol 15, No 3 (2022), Pagination: 1211-1218Abstract
Introduction: Alopecia is a hair loss that occur continuously and may occur in men, women and children. The causes of alopecia, including the use of cosmetics, medication, stress, postpartum period, hormonal disorders, and scalp infection. The purpose of this research is to determine the compounds contained in Petroselinum crispum that have the potential as antialopecia agents by predicting ligand-receptor binding and binding modes, predicting ADME by using Lipinski's rule, and also comparing the effectiveness with native ligand and minoxidil. Methodology: The process starts with protein and ligand structure preparation, then docking using Autodock Vina. Afterward, analyzed and visualized of the ligands docking, and predicted the ADME according to lipinski's rules using SwissADME and toxicity using PASS predistion. Result: There were 24 compounds found in Petroselinum crispum. Molecular docking simulation showed that six compounds had better binding affinities than minoxidil. Based on the results of prediction of ADMET values using the Lipinski rule and PASS Prediction, compound that are thought to have good activity is (+)–Marmesin compared to minoxidil. Conclusion: (+)–Marmesin to have better interactions with the androgen receptor, but not better than native ligands. thus, (+)–Marmesin can be used as antialopecia agents alternative terapy.Keywords
Alopecia, Androgen receptor, In silico, Petrocelinum crispum.References
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